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Ginkgo
- Medicinal Uses, Interactions, Side Effects, Dosage
Ginkgo biloba is one of the oldest living tree species. Almost extinct
following the Ice Age, the ginkgo tree survived only in Asia, and was imported
to Europe and America in the 18th century as an ornamental street tree. An extract
is prepared from the dried green leaves.
Uses and Benefits:
A standardized Ginkgo biloba extract (GBE) first became popular in Germany in the 1960s when a group of scientists found it to be particularly active while investigating the effects of exotic herbs on circulation. This extract was extensively researched and used for cognitive defects and peripheral vascular disorders in European countries, and is now commonly promoted for similar uses in the U.S, particularly for the treatment of dementia and Ihe enhancement of memory. GBE is used to treat circulatory impairment (cerebrovascular and peripheral arterial insufficiency), vertigo, tinnitus, impotence, asthma, allergies, premenstrual syndrome, depression, and many other disorders.
Pharmacology:
More than 40 components of Ginkgo biloba Ilave been identified. Two of the most important groups of active chemicals are the flavonoids (e.g., quercetin, kaempferol, isorhamnetin) and the terpene lactones or terpenoids, which include bilobalide and several ginkgolides (A, B, C, J, and M) GBE, standardized to 24% flavonoids and 6% terpenoids, and the individual constituents have been studied in hundreds of in vitro, animal, and human pharmacologic experiments.
In summary, GBE improves cerebral and peripheral bloodflow in animal and human experiments, at least in part via nitric oxide-induced vasodilation. The flavonoid components have antioxidant activity that can also prevent cellular damage. One or both 01" these effects result in protection against neuronal, myocardial, and retinal damage in laboratory experiments and animal models, especially resulting from hypoxia or ischemia. In vitro, the gink. golides (especially ginkgolide B) inhibit binding of platelet-activating factor (PAF), which is normally a potent mediator of inflammatory and allergic responses. Additionally, activation of various cerebral neurotransmitter systems (especially the cholinergic system) may contribute to ginkgo's cerebral properties. GBE causes behavioral changes in animals that include increased task performance and behavior adaptation, and produces enhanced alpha-wave activity on human EEG profiles that are similar to other cognitive-activator drugs such as tacrine.
While multiple biologic mechanisms have been well characterized, doses and routes of administration used in these experiments do not always correspond with oral doses in humans.
Clinical Trials:
Dementia and Cerebral Insufficiency-GBE has been used and studied in Europe for many years for the treatment of "cerebral insufficiency," an ill-defined syndrome consisting of dementia or cognitive defects and a group of related physical and affective symptoms (e.g., tinnitus, vertigo, fatigue, headache, depression, anxiety). A 1992 critical review evaluated controlled trials of GBE for the treatment of this syndrome. All but one trial reported positive results, but only eight trials were of acceptable quality or were well performed. Recent research has concentrated on defined diagnoses with more stringent inclusion criteria for dementia of the Alzheimer's type (OAT) and vascular or multi-infarct dementia (MID). In a recent systematic review, nine of double-blind, randomized, controlled trials met inclusion criteria for the treatment of mild-moderate OAT or MID.tatistically significant benefits were found in eight of nine trials. While some of these studies had methodologic faults, the overall results demonstrated that ginkgo appeared efficacious in delaying the clinical deterioration of patients with dementia or in bringing about symptomatic improvement.
Adverse Effects:
GBE is well tolerated. Less than 2% of patients develop side effects, which include mild gastrointestinal symptoms, headache, and dermal hypersensitivity. In most controlled clinical trials, the incidence of side effects is similar to that of placebo.
To date, seven case reports in the U.S. literature highlight the potential for bleeding complications, believed to be due to ginkgolide's inhibitory effects on PAF. Two cases were of sponta-neous subdural hematoma, two were of intracerebral hemorrhage ( One in a 78-year-old man who was also taking warfarin), and there was one case each of subarachnoid hemorrhage, spontaneous eye hyphema (in an elderly man also taking aspirin), and postoperative bleeding. The causality of the relationships is not firmly established, and there have been no reports of bleeding from any of the controlled clinical trials or the millions of patients who have been treated in European countries. Thus, any risk of bleeding appears to be extremely small. Similarly, seven cases of seizures associated with ginkgo use have been recently reported to the FDA, and several other anecdotal cases have been noted. Although causality is uncertain, these reports highlight the potential toxicity of an herb with potent pharmacologic properties.
Side Effects and Interactions:
Ginkgo extract given with trazodone was associated with acute CNS depression in an 80-year-old woman, which appeared to be reversed with flumazenil. In light of the in vitro action of ginkgo on PAF and the case reports of bleeding, ginkgo should be used cautiously with other medications that inhibit clotting or enhance the risk of bleeding.
Cautions:
Data from animal studies indicates no teratogenic or embryotoxic effects with ginkgo; however, there is no human data lor use in pregnancy or lactation. Excessive ingestion of qinkgo seeds (not the leaves) can result in an illness known in Japan as gin-nan poisoning, which includes seizures.
Preparations & Doses:
The usual dose of GBE demonstrated to be beneficial in the controlled clinical trials is 120-240 mg/day administered in divided doses (i.e., 40-80 mg taken two to three times a day). For chronic conditions, a 6-to 8-week trial of use has been typically recommended to evaluate efficacy. The GBE formulation is a concentrated 35-67:1 (mean 50:1) extract consisting of dried ginkgo leaves, which is standardized to contain 22-27% flavonoid glycosides and 5-7% terpenoids. This extraction technique also removes polyphenolic compounds including the potentially toxic and allergenic ginkgolic acids (to < 5 ppm).
Summary Evaluation
Ginkgo biloba contains many pharmacologically active constituents and is widely used for cognitive impairment, circulatory disorders, and many other indications. The best evidence for ginkgo's clinical efficacy is for mild-moderate dementia and for in· termittent claudication. However, benefits are likely to be small and have not been proven beyond a reasonable doubt. As a general memory-enhancer in the healthy adult, there is some evidence that GBE can improve selected cognitive testing such as speed of information processing. However, the optimal dose is unknown, and many studies failed to demonstrate beneficial effects; thus, the actual clinical and cognitive implications are unclear and inconclusive. Ginkgo's role as a potential therapy for many other indications is not well established. Standardized ginkgo extracts are generally well tolerated, although there may be a very small increased risk of bleeding.
Peter Thomas is a writer, who writes many great articles on herbal medicines for common
ailments and diseases. For more information on herbal remedies and home remedies visit our
site on health care at
http://www.health-care-tips.org/.
Jeanne Rose has been gracious enough to provide us with a excellent
CONDITIONING OIL and a BEVERAGE TEA FOR HAIR HEALTH.
Jeanne Rose is the founder of New Age Creations, the first body-care company in the United
States to use aromatherapy (since 1967). She is the Director of the Institute of Aromatic
Studies, principal tutor of both the Herbal Studies Course and the Aromatherapy Studies
Course by home-study. She brings 30 years of experience and personal research in her practice
of Aromatherapy.
The finest mixture of conditioning oils is
Jojoba,
Rosemary
and
Basil.
Equal parts of the oils are mixed, and 1 drop is used at a time.
Put the conditioning oil on your hand, rub your hand across your brush,
and then brush your hair. Remember to bend at the waist to release
tension from the neck and shoulder muscles and brush from the nape of
the neck all the way down to the ends of the hair.
One or 2 drops of oil on the brush is more than adequate for your
daily ritual.
BEVERAGE TEA FOR HAIR HEALTH
It is a well-known fact that shampoo and herbal hair rinse alone will
not transform drab, lanky hair into a mane of shining glory.
Good nutrition and daily exercise is most important. Various
nutrients are needed to keep the hair in good shape, such as
cysteine (500 mg. /day for at least 6 months), biotin and vitamins
A, B6, and E. Various herbs can also supply needed hair
nutrients- Nettle contains absorbable iron,
Horsetail contains silica, Oats and Comfrey contain calcium, and
Strawberry leaves and Lemongrass contain vitamin A. A vitamin- and
nutrient-supplying mixture of herbs that can be drunk as a tea is:
2 oz each of
Comfrey leaf,
Nettle,
Lemongrass,
and
Violet flowers or
Strawberry leaves
1 ounce each of
Kelp
or Dulse,
Beet tops,
Alfalfa, and
Lemon peel
1/2 oz each of
Hibiscus flowers,
Camomile
(also spelled Chamomile),
Oatstraw,
Horsetail,
and Mint
These herbs are mixed and bottled in a dry, lightproof container and stored.
The tea is brewed in the usual way, 1 teaspoon to 1 tablespoon of herbs to
1 cup of boiling water, steeped, strained, and drunk. Honey can be added if
desired. For best results the tea should be taken regularly over some period
of time, 2-4 cups per day.
Here is the book that takes over where "Herbs & Things" leaves off.
This book is the second in the Jeanne Rose Herbal Series*, covering the plants that are used externally for a healthy, natural and beautiful body. The recipes cover caring for the face, hair and body perfect for aromatherapists and casual users alike.
List Price: $17.95
Our Price: $12.57
The premier herbal that started the New Age (new & old) interest in the herbal wisdom of the past.
A compendium of practical and exotic herbal lore.
